UQ Holder! volume 1 is a sequel series to Negima! and features story and art by Ken Akamatsu.

Negi Springfield, the boy wizard of the manga Negima!, fought and won many battles. Now it is decades later and Negi's grandson, a little boy name Touta, dreams of leaving his quiet village and heading to the City. But first he must defeat his teacher... the immortal vampire, Evangeline!

UQ Holder! volume 2 features story and art by Ken Akamatsu.

Yukihime brings Tota and Kuromaru to UQ Holder HQ where they meet a whole team of immortals like them. As new recruits, they are shown a cold shoulder. To earn respect and become full-fledged members of UQ Holder, they must pass an initiation test.

Without any warning, Tota and Kuromaru are dropped into a murky underground maze. Their mission: to escape from this dark monster-infested labyrinth within eight years. Tota says he'll get out in a week. Can Tota beat the odds?

UQ Holder! 3 features story and art by Ken Akamatsu.

Tota, Kuromaru, and Karin are on a mission protecting the poor residents of the slums when they come under fierce attack by powerful enemies who seem to specialize in hunting down and killing immortals. Tota and Kuromaru take a nasty beat down and in a moment of desperation, Tota finds a new power that may be great or terrible or both!

UQ Holder volume 4 features story and art by Ken Akamatsu.

Tota meets Kirie Sakurame, a mysterious member of UQ Holder. Kirie looks like a little girl, but is apparently the wealthy patron of UQ Holder. Tota accompanies her on a trip to the tower to meet Karin (returning from the Moon), but the trip appears to have another purpose.

The powerful wizard Fate Averruncus, former ally of Tota's grandfather Negi, wants to take possession of Tota for reasons unknown. Despite having Karin, Ikku, Kirie, and Kuromaru with him, they stand little chance of stopping Fate, who possesses unfathomable power. Why does Fate want Tota? And can Kirie's secret plan succeed in stopping him?

UQ! Holder Volume 5 features story and art by Ken Akamatsu.

To get the drop on UQ Holder's true enemy, Fate Averruncus, Tota and the others head for Ama no Mihashira. At first, UQ Holder feels helpless before Fate's overwhelming strength, but then, with some help from Kirie's abilities, they manage to seize him! At last, for the first time in 20 years, Fate and Evangeline meet again. The moment their eyes lock in confrontation, the two hurl themselves into battle!